Broken Movement by John W. Krakauer & S. Thomas Carmichael

Author:John W. Krakauer & S. Thomas Carmichael
Language: eng
Format: epub
Tags: neuroscience; biology; medicine; neurophysiology; cellular neuroscience; molecular; neurology; motor skills; neurorehabilitation; rehabilitation; rehab; research; clinical; science; treatment; neuropsychology; arm and hand; behavior; physiology; motor control
Publisher: The MIT Press

4.13    Conclusions

Ischemic stroke occurs as a continuum in time of biological responses in the brain from initial ischemic cell death to secondary damage to regeneration and partial repair. Each element in this continuum is triggered by processes in the preceding stage. Stroke also occurs as a progressive spatially evolving biological response in the brain, from the initial ischemic core to radial brain regions at successive distances to the core and then to brain areas that are distant but connected to the core. The adult brain forms new connections after stroke, and these are part of the scarring response and also mediate recovery. The future challenge is to relate these processes occurring at the cellular and molecular level to equally fine-grained analysis of the recovered behavior they mediate. For example, the distinction between reparative and unbounded axonal sprouting is likely a matter of degree. It will be necessary to deliver pharmacological modulators of neural repair within well defined rehabilitative training paradigms (type, timing, intensity) to promote optimal repair.

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